Dortmund's European hopes remain alive as they face Bayern Munich in Der Klassiker. RB Leipzig, after a scramble against Monchengladbach, may struggle again against Freiburg, while the latter will be hoping to bounce back against Bayer Leverkusen.
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With Bayern Munich stumbling, and RB Leipzig and Eintracht Frankfurt finding rich veins of form, the top of the table is looking interesting again, with just two points in it. At the other end of the table, a good chance this weekend for Mainz to claw their way into safety.
The results of this week's games, the second set of first-leg matches, should prove easier to call. Famous last words, perhaps, but favourites Manchester City and Bayern Munich should ease by Borussia Monchengladbach and Lazio, respectively. The tightest match to call is Atletico Madrid versus Chelsea, though we opt for the Spaniards, while Real Madrid should also triumph over Atalanta.
The last 16 kicks off this week: Barcelona should win at the Nou Camp as PSG miss Neymar; expect a draw on neutral ground between Liverpool and RB Leipzig; while Juventus and Dortmund should win away, over Porto and Sevilla, respectively.
While Bayern Munich are the undisputed kings of German football, Dortmund had hoped to put an end to their status as the perennial bridesmaid. Now they're even outside a Europa League spot - but have a chance to notch a much-needed win this weekend. In stark contrast, Wolfsburg are hunting a fifth straight Bundesliga victory.
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With Bayern Munich firmly at the top, the table seems to be taking shape - but Frankfurt's recent run takes them into the top four and they hunt for their first ever Champions League qualifying spot. Bayer Leverkusen and Borussia Dortmund should rediscover their winning ways having dropped points in recent weeks.
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