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Bayern Munich should come away with three points, but RB Leipzig may struggle to stay in touch at the top. Fourth-placed Frankfurt will have to work hard to see off an in-form Union Berlin and protect their European spot.
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All four home teams hold away-goal leads, suggesting that picking the winners shouldn't be too tricky. At current odds, Man City are still favoured for the title, just ahead of champs Bayern Munich. Real Madrid and Chelsea are favourites - but might Atalanta cause on upset over the Spanish giants?
With what should be a straight-forward victory this weekend for the league leaders, second-place RB Leipzig need to beat fourth-placed Frankfurt to ensure the two-horse race at the top of the table remains tight.
We're not expecting any surprises from the first four second-leg matches - three of the teams now playing at home go into the game with away-goal leads, and there's little to suggest that they wont see the job through. The exception is Juventus, but their track record at home suggests they should triumph.
Dortmund's European hopes remain alive as they face Bayern Munich in Der Klassiker. RB Leipzig, after a scramble against Monchengladbach, may struggle again against Freiburg, while the latter will be hoping to bounce back against Bayer Leverkusen.
UFC 259 takes us back to Las Vegas, with three championship fights topping the 15-fight card. The Cloudbet Blog takes a closer look at the three headline bouts to offer you some smart bettor insight ahead of all the action.
With Bayern Munich stumbling, and RB Leipzig and Eintracht Frankfurt finding rich veins of form, the top of the table is looking interesting again, with just two points in it. At the other end of the table, a good chance this weekend for Mainz to claw their way into safety.
The results of this week's games, the second set of first-leg matches, should prove easier to call. Famous last words, perhaps, but favourites Manchester City and Bayern Munich should ease by Borussia Monchengladbach and Lazio, respectively. The tightest match to call is Atletico Madrid versus Chelsea, though we opt for the Spaniards, while Real Madrid should also triumph over Atalanta.